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The cytotoxicity of the thirteen active compounds, expressed as the concentration necessary to cause a 50 per cent inhibition of growth, varied 2000-fold from an average of 0.000005 mM in the case of aminopterin to 0.008 in the case of thio-TEPA; but in general, a given compound was equally active against both normal and malignant cells.
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Sixteen (16) out of fifty (50) isolated bacteria showed different degrees of antagonism (25-67%) against both fungi F. oxysporum and C. melongenae. Among them, four (4) isolated bacteria (isolates A4, C1, C2, and E2) exhibited strong antagonism (more than 50% mycelial growth inhibition) against …
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These bacteria produce several secondary metabolites including antimicrobial compounds. The objectives of this study were to isolate and identify EPNs and their symbiotic bacteria from Mae Wong National Park, Thailand and to evaluate the antibacterial activities of symbiont extracts against drug resistant bacteria.
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Screening of bacterial endophytes as potential biocontrol agents against soybean diseases. Karla Bianca de Almeida Lopes, Agronomy Department, Universidade Estadual de Londrina, Londrina, Brazil. Search for more papers by this author. Valéria Carpentieri-Pipolo,
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Against all the tested bacterial strain, we observe methanol extract of all the samples showing much better antibacterial activities in contrast to aqueous extract, which may be because of organic nature of methanol and also for the reason of its high capacity to dissolve more organic and active antimicrobial compounds (Cowan, 1999).
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A novel three-step combination of in vitro and ex vivo screening was established to massively screen host derived lactic acid bacteria (LAB) from the broiler chicken intestine with inhibitory activity against Escherichia coli.In a first step, a massive sample pool consisting of 7102 broiler-derived colonies from intestinal contents were established and sub-cultured.
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There are several antimicrobials used in farm animals worldwide, therefore testing for susceptibility and resistance of bacteria to different drugs needs to be conducted to assess the effectivity of said antimicrobials against zoonotic and pathogenic bacteria. It …
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The compounds are stated to be useful against a broad spectrum of bacteria, fungi and parasites. ... most preferably positions 34 and or 37 of the stated tRNAs. The screening step may be carried out in a host cell, wherein the corresponding host cell tRNA (i.e., the tRNA that binds to the same amino acid) is modified differently as compared to ...
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Joseph Cannova - Screening Mycobacteria marinum Mutants for Iron Sensitivity and the Role of ... Discovery of Novel Antibiotics against Bacterial Diseases ... Towards the Synthesis of Phosphoramides and Sulfonamides via Organophosphorous Activation
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These nanocomposites have shown much more efficiency as anti-bacteria against G.xylinus, anti-fungi against yeast cells and enzyme immobilization against AChE enzyme. This investigation showed that when the GO acts as a bed for the phosphoramide ligands, these ligands would be soluble in different solvents and would be needed to be used in less ...
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Virtual screening (VS) or in silico screening, is an increasingly used method for the identification of novel leads from large chemical libraries. Both ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) protocols have emerged as popular tools in early drug discovery and development process and among all VS ...
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Screening of Antimicrobial Activity by Cross Streak Method Against Five Bacterial Pathogenic Strains. Among all the strains only D1 has shown good antimicrobial activity against Klebsiella and ...
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testing new drugs. In parallel there has been an increase in antimicrobial resistance of bacteria, fungi, parasites and some viruses to multiple active agents.[6] For example, antibiotics are used beside bacteria and antifungal are used against fungi. Agents that kill
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In the United States, reported prevalence of bacterial vaginosis among pregnant women ranges from 5.8% to 19.3% and is higher in some races/ethnicities.1 Bacterial vaginosis during pregnancy has ...
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Screening and evaluation of indigenous bacteria as a probiotic and biocontrol agent against Vibrio harveyi in Litopenaeus vannamei post larvae. Maryam Mirbakhsh. Download PDF. Download Full PDF Package. This paper.
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Natural phosphoramides such as N-phosphocreatine and phosphoramides shown in Figure 18 are formed ... The antibiotic is active against gram-negative bacteria of various taxonomic groups, as well as some gram-positive bacteria. ... Phosalacine was isolated from the fermentation broth of actinomycete strain KA-338 during the screening of ...
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Screening of plants is common practice to develop resistant varieties against a particular stress (Ashfaq et al. 2016). Host-plant resistance would serve as a beneficial tool in managing BLB in rice crop (Banito et al. 2012).
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Structure based virtual screening-driven identification of monastrol as a potent urease inhibitor. Journal of molecular graphics & modelling, 2013. Zaheer Qasmi. Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper.
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The donor numbers (DN) of a series of 20 phosphoramides with general structure (R2N)(X2N)(Y2N)P=O (with R,X and Y alkyl radicals, nitrogen-heterocycles or hydrogen atoms) were revised on the basis of a series of rather simple considerations. It is shown that all the phosphoramides considered even after the revision are characterized by high DN.
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To establish the pharmacological rationale for its traditional use, the powdered root, stem-bark and leaves were extracted with water and ethanol. All fractions were subjected to phytochemical screening and antimicrobial activity against gram-positive and gram-negative bacteria using the disc-diffusion method.
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to phosphorus. The majority of the compounds (5a-h) exhibited moderate activity against bacteria and fungi when compared to that of the respective standards. Experimental Section General procedures. All melting points were determined in open capillary tubes on a Mel-temp apparatus and are uncorrected.
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() were active against the tested biofilm-forming bacteria. Eight bacterial epiphytes were able to inhibit the growth of biofilm-forming bacteria with a range of inhibition between 0,82 mm – 7,73 mm, with a total of 11 biofilm-forming bacteria were inhibited. On the other hand, 6 bacterial …
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The use of immobilized bioreactors proved to be advantageous as well, not only to increase the length of fermentation but also to increase cell concentrations and reaction rates (Qureshi, Annous, et al., 2005).Immobilized cell techniques have already been applied for ABE fermentation since the 1980s (Krouwel et al., 1983), and various supports and reactor configurations (Table 10.4) have ...
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tion activity against all pathogenic bacteria used in this study, with the most positive results against S. aureus and E. faecalis and the least against P. aeruginosa2) (Table˛ Crude extracts showed the highest biofilm destruction activity against S. aureus(%)sing isolate JB 18B. Microscopicobservations
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Abstract. Antibiotic susceptibility testing (AST) specifies effective antibiotic dosage and formulates a profile of empirical therapy for the proper management of an individual patient's health against deadly infections. Therefore, rapid diagnostic plays a pivotal role in the treatment of bacterial …
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Photorhabdus and Xenorhabdus are symbiotic with entomopathogenic nematodes (EPNs) of the genera Heterorhabditis and Steinernema, respectively. These bacteria produce several secondary metabolites including antimicrobial compounds. The objectives of this study were to isolate and identify EPNs and their symbiotic bacteria from Mae Wong National Park, Thailand and to evaluate the antibacterial ...
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An IGRA is a blood test that can determine if a person has been infected with TB bacteria. An IGRA measures how strong a person's immune system reacts to TB bacteria by testing the person's blood in a laboratory. Two IGRAs are approved by the U.S. Food and Drug Administration (FDA) and are available in the United States:
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The result of the antimicrobial screening Table 2, showed that Pteleopsis habeensis crude Methanolic stem bark extract has antibacterial activities against gram positive and gram negative bacteria, but it showed no antifungal effect against the tested fungus; C.albicans. Escherichia coli were observed to be
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A preliminary screening for antilisterial activities of Gram-positive, catalase negative new isolates was performed according to Lewus et al. (Reference Lewus, Kaiser and Montville 1991). Bacterial suspensions (2 µl) of the 815 tested isolates were spot inoculated onto TSA-ye agar (trypticase soy agar supplemented with 6 g/l of yeast extract ...
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Phosphoramide. Phosphoramides having an aziridine functionality in their molecules are used as cytostatics, mutagenes, and sexual sterilizers for harmful insects [14]. From: Chemistry and Application of H-Phosphonates, 2006. Download as PDF. About this page.
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A high-throughput antagonistic assay was developed to screen for bacterial isolates capable of controlling the maize fungal phytopathogen Fusarium verticillioides.This assay combines a straightforward methodology, in which the fungus is challenged with bacterial isolates in liquid medium, with a novel approach that uses the plant lectin wheat germ agglutinin (WGA) coupled to a fluorophore ...
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The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
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